Immunomodulation as The Desired therapy in Some Cases of Allergic Diseases

• Autorzy: Joanna Mazurek
• Języki publikacji: EN

Abstrakty

EN

There has been a strong belief for many years that there is no pathogenic connection between allergy and autoimmunity. Academic books usually describe the disparate immune mechanisms playing pivotal role in pathogenesis of allergic and autoimmune diseases. A simplified hypothesis of Th1/Th2 balance disorder represents an accepted model of the diseases. Recent findings have suggested that there is no clear dichotomy between allergy and autoimmunity. Both of them result from dysregulation of the immune system. The systematic review of the literature was performed searching electronic databases for the pathologic and clinical intersection of allergic a autoimmune conditions. Research is currently focused on the key elements that regulate the immune response. Mast cells, which play important role in allergic inflammation, make it likely that they have profound effects on numerous autoimmune conditions. Environmental stress and proinflammatory cytokines may activate the protein kinases in both conditions. The presence of autoantibodies in some allergic conditions such asthma or atopic dermatitis may point out an autoimmune background in some cases. Genetic factors lead the development and process of immunologic diseases. Data suggest a close relation between genepolymorphism of HLA and cytokines and development of autoimmunity and allergy. The infection also may play an important role in the induction of the diseases. Despite the use of more effective anti-inflammatory drugs, the progressionof many allergic and autoimmune diseases may not be halted. Better knowledge about the considerable communication between complex signalling pathways pointout immunomodulation as the key to successful therapy of both allergic and autoimmune conditions(original abstract)

Słowa kluczowe

EN

Medications; Production of medicines

PL

Leki; Produkcja leków

• Czasopismo: Journal of Health Policy and Outcomes Research
• Rocznik: 2014
• Numer: nr 1
• Strony: 32--45

Twórcy

autor

Joanna Mazurek

• Department of Clinical Immunology and Allergology Military Institute of Medicine

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Identyfikatory

DOI

10.7365/JHPOR.2014.5.3