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53--61
Tytuł artykułu

Cost-effectiveness Study of Diagnosis Strategies of Acute Viral Infections in Ukraine

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Efficient and accurate laboratory diagnosis of viral pathogens is of primary importance for clinical care in terms of health care system reforms. The methodological approach of cost-effectiveness analysis of laboratory diagnosis tests for viral infections from payer's perspective was presented. We argue on an expository software-based technique for assessing the costs of newer laboratory tests. We applied decision tree modeling techniques to compare expected costs and effectiveness of strategies for the diagnosis of viral infections. We conducted univariate and Monte-Carlo method based multivariate sensitivity analysis. Operating characteristics of diagnostic methods have been described. The analytical modeling, based on the cost-effectiveness method for the detection of human viruses were conducted. We considered three strategies: the use of only rapid tests for detection of one pathogen - adenoviruses; multiplexed PCR for 12 viruses, including adenoviruses; and combined strategy with confirmation of negative result of rapid test via use of PCR method. Univariative analysis showed that the cost savings achieved by use of PCR were 45% less per unit of effectiveness than the cost per effectiveness unit of rapid tests. Moreover multivariate probabilistic analysis, taking into account uncertainty of all operating characteristics, showed similar results for PCR method(original abstract)
Słowa kluczowe
Czasopismo
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Strony
53--61
Opis fizyczny
Twórcy
  • National medical academy of postgraduate education, Kyiv, Ukraine
  • National medical academy of postgraduate education, Kyiv, Ukraine
autor
  • Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
  • Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
  • Department of Applied Mathematics, the National Technical University of Ukraine
Bibliografia
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  • Zaitsev IA, Miroshnichenko VA The rapid tests in the diagnosis of viral hepatitis with parenteral mechanism of transmission of pathogens. Laboratory Diagnostics 2005: №2: 41-43
  • Dzyublik IV, Samborska JF, Kostenko IG et al, Laboratory diagnosis of infection in terms of practical virology laboratory: Guidelines .Kiyv 2012. 24 p.
  • Doan CI, Dove A, Onishchenko AV Laboratory studies in epidemiological surveillance system for influenza and SARS. Preventive Medicine 2012; №1: 0-15
  • Doan CI. Rapid tests in the system of laboratory tests for HIV in Ukraine. Preventive Medicine 2011; №1: 4-9
  • Kramareva SA, Evtushenko VV, Palatna LO, et al. Flu in children. Current approaches to diagnosis and treatment. Clinical Immunology. Allergology. Infectiology 2010; N98: 1-4
  • Felder St., Mayrhofer T.. Medical Decision Making, Berlin: Springer.2011, 200 pp.
  • Cook AG. Forecasting for the pharmaceutical industry: models for new product and in-market forecasting and how to use them. Gower Publishing Limited. 2006
  • Gnedenko BV. The course of probability theory, 6th ed.] Moskow: Nauka. 1988 (in Russian)
  • Von Neumann J, Morgenstern O. Theory of games and economic behavior (2nd ed.). Princeton: Princeton University Press.1947, 776 pp
  • Roberts MS, Smith KJ. (2010). Decision Modeling Techniques. Cost-effectivenesss: from theory to practice. (Ed. by Renee J.G. Arnold). Boca Raton: CRC Press (Taylor and Francis Group, LLC): 37-46
  • Pastuhov NV, Spichak IV. Design of the information system of drug provision of health facilities. Person and health 2005; N 3:73-79
  • Dzyublyk YaO, Obertins'ka OV. Algorithm etiological diagnosis of community acquired lower respiratory tract infections. Ukrainian Pulmonology Journal 2013; N 3: 112-113
  • Dzyublyk ІV, Obertins'ka OV, Dzyublik YaO., Sambors'ka І.F., Stepchenkova T.V., Kovalyuk OV, Voronenko SG, Kovalishin GG. Rapid tests for etiologic diagnosis of infectious human diseases, Kiyv: Methodical recommendations: 2013 , 41 pp.
  • Tolubaiev V, Zaliska O, Irynchyn G, Piniazhko O, Maksymovych N. COPD in Ukraine: overview of the status and prospects for improvements and developments in health care system. Journal of Health Policy&Outcones Research 2015; № 1: 66-75
  • Yagudina RI, Zinchuk IYu. Cost-effectiveness studies of drugs for the diagnosis of tuberculosis infection. Farmakekonomika 2013:Vol.6, N.1: 11-15
  • Gajkovaya L B, Vavilova TV, Sirotkina OV. The economic rationale for using the method of flow cytometry to assess the functional activity of platelets in patients receiving antiplatelet drugs. Handbook of Head; N 8: 73-79
  • Therapeutic and Diagnostic Device Outcomes Research (Ed. by Stacey J. Ackerman). ISPOR (2011), 332 pp.
  • Shillcutt S, Morel C, Goodman C. Cost-effectiveness of malaria diagnostic methods in sub-Saharan Africa in an era of combination therapy. Bulletin of World Health Organization, 2008; Vol. 86: 101-110
  • Mahony JB, Blackhouse G, Babwah J. Cost analysis of multiplex PCR testing for diagnosing respiratory virus infections. Journal of Clinical Microbiology 2009: Vol. 47, N 9: 2812-2817
Typ dokumentu
Bibliografia
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Identyfikator YADDA
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