Cost-Effectiveness Analysis of Human Papillomavirus (HPV) Vaccination Using Cervarix® as an Extension to the Cervical Cancer Prevention Programme in Poland

• Autorzy: Katarzyna Wepsięć , Magdalena A. Mrożek-Gąsiorowska , Marcin Gąsiorowski , Oskar Dankiewicz , Andrzej Nowakowski
• Języki publikacji: EN

Abstrakty

EN

Background: The aim of the study was to estimate the cost-effectiveness of addition of human papillomavirus (HPV) vaccination to the Polish cervical cancer prevention programme. Methods: A cost-utility analysis was conducted. A lifetime Markov model, adapted to Polish settings, was used to compare the costs and health outcomes of the two strategies, i.e. the existing cervical cancer prevention programme with or without universal HPV vaccination in girls at the age of 14. Results: Assuming that the whole cohort was vaccinated (100% vaccination coverage), the estimated lifetime risk of developing cervical cancer would be reduced from 0.95% to 0.23%; therefore, 1311 cases of cervical cancer and 681 deaths due to cervical cancer would be prevented in a cohort of 182,000 girls aged 14 years.If the assumed vaccination coverage was 24%, the cost of gaining an additional quality-adjusted life year (QALY) due to HPV vaccination as an extension of the cervical cancer prevention programme would be PLN 52,737.91/QALY and PLN 76,288.47/QALY from the public payer's perspective and the common perspective of the public payer and the patient, respectively.This cost effectiveness is maintained for different parameter assumptions in the sensitivity analysis. Even with high assumed discount rates for costs and health outcomes (5% for both), the ICUR value was still lower than the cost-effectiveness threshold (PLN 105,801 per QALY). Conclusion: Addition of HPV vaccination to the cervical cancer prevention programme in Poland is a highly cost-effective intervention.(original abstract)

Słowa kluczowe

EN

Preventive health care; Health care protection; Illness

PL

Profilaktyka zdrowotna; Ochrona zdrowia; Choroby

• Czasopismo: Journal of Health Policy and Outcomes Research
• Rocznik: 2013
• Numer: nr 2
• Strony: 32--41

Twórcy

autor

Katarzyna Wepsięć

• GSK Services Sp. z o.o., Warszawa, Poland

autor

Magdalena A. Mrożek-Gąsiorowska

• Pracownia HTA, Kraków, Poland

autor

Marcin Gąsiorowski

• Pracownia HTA, Kraków, Poland

autor

Oskar Dankiewicz

• Pracownia HTA, Kraków, Poland

autor

Andrzej Nowakowski

• Central Teaching Hospital, Warszawa, Poland

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Identyfikatory

DOI

10.7365/JHPOR.2013.4.4