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2017 | nr IV/2 | 1687--1698
Tytuł artykułu

Synthesis of Bees' Chitosan Based Hydrogels Containing Aloe Vera

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Chitosan based hydrogels due to their specific properties and structure belong to the group of materials widely used in medicine. They are used as drug carriers with controlled release of active substances and in the preparation of innovative wound dressings. The main aim of the conducted research was the choice of the most favorable parameters for carrying the cross-linking reaction by means of UV radiation and microwaves. Subsequently, an adequate composition of the mixture containing chitosan and gelatin for further modification of such prepared the polymer matrix with Aloe vera extract was selected. Subsequently, an impact of introduction of Aloe vera extract into hydrogel on its physicochemical properties and structure was determined. The scope of the research included the measurement of swelling abilities of hydrogels in distilled water and selected simulated body fluids as well as incubation studies aimed at determination of tendency of prepared materials to degradation in previously mentioned fluids and their compatibility in relation to such environments. In order to characterize the chemical structure of the polymers and impact of incubation on this structure spectroscopic analysis was performed. Microscopic analysis was used to define the surface morphology of the hydrogels. Moreover, materials containing Aloe vera extract were subjected to the studies of release of additive from hydrogel matrix. Research was conducted both in acid and alkaline environment.(original abstract)
Rocznik
Numer
Strony
1687--1698
Opis fizyczny
Twórcy
  • Cracow University of Technology
  • Cracow University of Technology
  • Cracow University of Technology
Bibliografia
  • Anjum S., Arora A., Alam M.S., Gupta B. (2016). Development of antimicrobial and scar preventive chitosan hydrogel wound dressings. International Journal of Pharmaceutics. 508, 92-101.
  • Baruah A., Bordoloi M., Baruah H.P.D. (2016). Aloe vera: A multipurpose industrial crop. Industrial Crops and Products. 94, 951-963.
  • Bhattarai N., Gunn J., Zhang M. (2010). Chitosan-based hydrogels for controlled, localized drug delivery. Advanced Drug Delivery Reviews. 62, 83-99.
  • Cieślik E., Turcza K. (2015). Właściwości prozdrowotne aloesu zwyczajnego Aloe vera (L.) Webb. (Aloe barbadensis Mill.). Postępy Fitoterapii 16, 117-124.
  • Guiseppi-Elie A. (2010). Electroconductive hydrogels: Synthesis, characterization and biomedical applications. Biomaterials. 31, 2701-2716.
  • Kirschner C.M., Anseth K.S. (2013). Hydrogels in healthcare: From static to dynamic material microenvironment. Acta Materialia. 61, 931-944.
  • Patrulea V., Ostafe V., Borchard G., Jordan O. (2015). Chitosan as a starting material for wound healing applications. European Journal of Pharmaceutics and Biopharmaceutics. 97, 417-426.
  • Radha M.H., Laxmipriya N.P. (2015). Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. Journal of Traditional and Complementary Medicine. 5, 21-26.
  • Rajeswari R., Umadevi M., Pushpa R., Selvavenkadesh S. (2004). Aloe vera: The Miracle Plant Its Medicinal and Traditional Uses in India. Journal of Pharmacognosy and Photochemistry. 1, 118-124.
  • Sanchez-Machado D.I., Lopez-Cervantez J., Sendon R., Sanches-Silva A. (2017). Aloe vera: Ancient knowledge with new frontiers. Trends in Food Science & Technology. 61, 94-102.
  • Sepantafar M., Maheronnaghsh R., Mohammadi H., Radmanesh F., Hasani-sadrabadi M.M., Ebrahimi M., Baharvand H. (2017). Engineered Hydrogels in Cancer Therapy and Diagnosis. Trends in Biotechnology. 35(11), 1074-1087.
  • Silverstein R.M. (2015). Spectrometric identification of organic compounds, John Wiley & Sons.
  • Witthayaprapakorn C. (2011). Design and Preparation of Synthetic Hydrogels Via Photopolymerization for Biomedical Use as Wound Dressings. Procedia Engineering. 8, 286-291
Typ dokumentu
Bibliografia
Identyfikator YADDA
bwmeta1.element.ekon-element-000171496388

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