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2017 | t. 18, z. 10, cz. 3 Organizacja i zarządzanie w ochronie zdrowia | 203--212
Tytuł artykułu

Zarządzanie w profilaktyce onkologicznej na przykładzie suplementacji selenem (Se)

Treść / Zawartość
Warianty tytułu
Management in Oncological Prevention on the Example of Selenium Supplementation (Se)
Języki publikacji
PL
Abstrakty
Celem niniejszej pracy jest przedstawienie w świetle literatury przedmiotu pozytywnego wpływu selenu (Se) na zapobieganie nowotworom narządów płciowych u kobiet i nowotworom gruczołu krokowego oraz jako istotnego elementu w profilaktyce onkologicznej. (fragment tekstu)
EN
Introduction. Genital cancers in women and prostate cancer are among the most common malignant tumors occurring in Poland. To reduce the risk of developing the above-mentioned neoplasms need proper management of prophylaxis, in which the use of selenium may be an important item. Numerous studies conducted for many years in Poland and at dawn have demonstrated the significant effect of selenium in the prevention of cancer - including genital cancers in women and prostate cancer.
The aim of this work is to indicate the influence of selenium (Se) on cancer prevention as an important element in the prevention of female genital cancer and prostate cancer. So far, the largest epidemiological studies on the relationship between serum selenium and subsequent cancer development have proved that low serum selenium levels may increase the risk of certain cancers in men and women, especially genital cancers. Numerous studies conducted on a group of women and men showed that the threshold value of serum selenium concentration is associated with an increased risk of cancer - is <85μg / l (p = 0.019, OR-2.7). Epidemiological studies carried out in various countries, and above all in the Scandinavian countries and the United States, showed a negative correlation between the amount of selenium consumed and the incidence of cancer in humans. It has also been shown to reduce the concentration of this micronutrient in the blood of patients with oncological diseases in comparison with the values obtained in healthy people. The results of numerous national and international prospective studies indicate that low selenium intake and or serum/plasma nails concentration is a high risk marker for the majority of cancers, including genital cancers in women and prostate tumors; is an important element in the management of preventive oncology activities. (original abstract)
Twórcy
  • Państwowa Wyższa Szkoła Zawodowa w Wałczu
  • Uniwersytet Szczeciński
autor
  • Uniwersytet Szczeciński
  • Uniwersytet Medyczny w Białymstoku
Bibliografia
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  • Das N.P., Ma C.W., Golman M. (1986), Serum selenium concentrations in ovarian cancer patients using a simplified fluorimetric procedure, "Biol. Trace Elem. Res.", n.10, No. 1.
  • Dróżdż M., Tomala J., Jędryczka A. (1989), Concentration of selenium and vitamin E in theserum of women with malignant genital neoplasms and their family members, "Polish Gynecology" (polish), n. 60, No. 3.
  • Duffield-Lillico A.J., Dalkin B.L., Reid M.E., Turnbull B.W., Slate E.H., Jacobs E.T., Marshall J.R., Clark L.C. (2003), Nutritional prevention of Cancer Study Group, Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial, "BJU Int.", n. 91, No 2.
  • Etminan M., Gerani M.F., Gleave M., Chambers H. (2005), Intake of Se and the prevention of prostate cancer: a systematic review and meta - analysis, "Cancer Causes and Control", n. 16, No 4.
  • Frei B. (1993), Natural antioxidants in Human Health and Disease, "Academic Press Inc., N.Y.", n. 1, No. 2.
  • Gać P., Pawlas K. (2011), Stężenie selenu we krwi w różnych populacjach osób zdrowych i chorych - przegląd piśmiennictwa z lat 2005-2011. "Medycyna Środowiskowa", n.14, No 1.
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  • Lippman S.M., Klein E.A., Goodman P.J., Lucia M.S., Thompson I.M., Ford L.G., Parnes H.L., Minasian L.M., Gaziano J.M., Hartline J.A., Parsons J.K., Bearden J.D. (2009), Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E, Cancer Prevention Trial (SELECT), "JAMA", n. 301, No. 1.
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  • Roszkowski K., Jóźwicki W., Błaszczyk P., Mucha-Malecka A., Sionek A. (2011), Oxidative damage dNA: 8-oxoGua and 8-oxodG as molecular markers of cancer, "Med. Sci. Monit.", n. 17, No. 6.
  • Rzaeva N.A., Abdullaev F.I., Ivanova T.P., Dobrynin Ia.V. (1985), Cytotoxic action of selenium - containing compounds on cultured cells of human ovarian carcinoma, "Eksp. Onkol.", n. 7, No. 6.
  • Sabichi A., Lee J.J., Taylor R.J., Thompson M., Miles B.J., Tanger C.M. (2006), Selenium accumulation in prostate tissue during a randomized controlled short-term trial of l-selenomethionine: a Southwest Oncology Group Study, "Clin. Cancer Res.", n. 12, No. 4.
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  • Sieja K., Sygit K. (2016), Znaczenie selenu (Se) w prewencji i terapii nowotworów u człowieka, Wydawnictwo Naukowe Uniwersytet Szczeciński, Szczecin.
  • Slattery M.L., Abbott T.M., Overall J.C. Jr., Robinson L.M., French T.K., Jolles C., Gardner J.W., West D.W. (1990), Dietary vitamins A, C and E and selenium as risk factors for cervical cancer, "Epidemiology", n. 1, No. 1.
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Bibliografia
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