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2017 | nr 2 | 23--30
Tytuł artykułu

VaxigripTetra (Quadrivalent Influenza Vaccine) - Evidence for Clinical and Economic Benefits from Vaccination in Population Aged 65 and Over in Poland

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Background: Vaccination is considered to be the most effective way of preventing influenza related-illnesses and their complications, which is particularly important in elderly population (aged 65+), often characterized with more rapid and severe clinical course of infection. Quadrivalent influenza vaccines (QIV) have been developed to avoid the poor antigenic match observed in the trivalent formulation vaccine (TIV). Methods: The study assess the immunogenicity, cost-effectiveness and impact on the Polish budget of inactivated quadrivalent influenza vaccine (VaxigripTetra), assuming its reimbursement in the active immunization of adults 65 years of age and older. Results: As clinical results have shown, non-inferior immunogenicity of QIV to each TIV for the shared strains and superior immunogenicity of QIV to each TIV for the alternate B strain. The inactivated QIV was well tolerated. VaxigripTetra is a highly cost-effective option compared to the strategy of "no vaccination" (ICUR=14,988 PLN/QALY - payer's + patients' perspective [PPP+P], ICUR=6,838 PLN/QALY - payers' perspective [PPP]) and also to TIV (ICUR=121,418 PLN or ICUR=114,360 PLN, respectively). The increase of the public payer's expenditures - 9.0-23.3 million PLN annually - will result in additional health effects: 1,091 - 4,805 GP visits, 175-771 hospitalizations and 74-326 deaths avoided per year. Conclusions: VaxigripTetra reimbursement could trigger a faster switch from TIVs to QIVs and at the same time could increase the vaccine coverage of the elderly population in Poland, which would lessen the ILI-related negative impact on that population at a reasonable cost to the healthcare system, while providing some savings to society.(original abstract)
Rocznik
Numer
Strony
23--30
Opis fizyczny
Twórcy
  • Aestimo s.c., Cracow, Poland
  • Aestimo s.c., Cracow, Poland
  • Aestimo s.c., Cracow, Poland
  • Aestimo s.c., Cracow, Poland
  • Aestimo s.c., Cracow, Poland ; Jagiellonian University Medical College, Cracow, Poland
autor
  • Sanofi-Aventis Sp. z o.o., Warsaw, Poland
  • Sanofi-Aventis Sp. z o.o., Warsaw, Poland
  • Sanofi-Aventis Sp. z o.o., Warsaw, Poland
Bibliografia
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  • Toback S.L., Rothstein E., Bhatt P., Carr W., Ambrose C.S.: In-office influenza vaccination by US pediatric providers varies greatly and is higher among smaller offices. Clin Pediatr (Phila) 2012; 51: 551-559.
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  • U.S. Food and Drug Administration 2007. Guidance for Industry: Clinical Data Needed to Support the Licensure of Seasonal Inactivated Influenza Vaccines. Available from: https://www.fda.gov/downloads/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/Vaccines/UCM091985.pdf.
  • European Medicines Agency 2016. Guideline on Influenza Vaccines. Non-clinical and Clinical Module. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2016/07/WC500211324.pdf.
  • Pépin S., Donazzolo Y., Jambrecina A., Salamand C., Saville M.: Safety and immunogenicity of a quadrivalent inactivated influenza vaccine in adults. Vaccine. 2013; 31: 5572-5578.
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  • Ustawa z dnia 12 maja 2011 r. o refundacji leków, środków spożywczych specjalnego przeznaczenia żywieniowego oraz wyrobów medycznych. (Dz.U. 2011 nr 122 poz. 696) Available from: http://isap.sejm.gov.pl/DetailsServlet?id=WDU20111220696.
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
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