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2018 | nr 1 | 13--19
Tytuł artykułu

The Combination of Angiotensin Converting Enzyme Inhibitors, Diuretics and Non-Steroidal Anti-Inflammatory Drugs in the Routine Community Pharmacy Settings in Poland: The Unrecognized Problem of 'Triple Whammy'. A Pilot Analysis.

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Background: 'Triple Whammy' defined as a combination of angiotensin converting enzyme inhibitors/angiotensin receptor antagonist, diuretics and non-steroidal anti-inflammatory drugs remains an important clinical problem, particularly in patients with risk of renal impairment. Community pharmacy settings are considered to be an appropriate place for detection and solving of this drug-related problem. Objectives: To estimate the frequency of 'Triple Whammy' in a routine community pharmacy setting in Poland by analysis of data obtained from refilled prescriptions. Methods: We conducted anon-interventional, observational retrospective study to assess the rate of 'Triple Whammy" cases in a community pharmacy setting in Poland. We reviewed 14243 prescriptions to find 'Triple Whammy' cases. The analyzed prescriptions were refilled between the 1.01.2016 and 31.05.2016 in one single community pharmacy in Poland. Results: The average age of all patients identified with 'Triple Whammy' was 68 (range, 56-91). We identified 12 prescriptions with 'Triple Whammy' among all cases, receiving most frequently ramipril (n=8 patients), diclofenac (n=6) and ketoprofen (n=5). Moreover, other medications that were prescribed to patients during the study analysis time period included proton pump inhibitors such as pantoprazole (n=3) and omeprazole (n=2), opioid analgesics - tramadol (n=1) in the fixed-dose combination with paracetamol, and one antihyperglycemic medication - metformin (n=1). Conclusions: 'Triple Whammy' should be considered as a potential drug-related problem in Poland. Our study suggests that geriatric population is particularly affected by this drug-related problem, and, consequently, pharmaceutical care is predominantly necessary among this cohort. (original abstract)
Słowa kluczowe
Rocznik
Numer
Strony
13--19
Opis fizyczny
Twórcy
  • Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Poland
  • Medical University of Gdansk, Poland
  • 10th Military Research Hospital and Polyclinic Independent Public Healthcare Center, Bydgoszcz, Poland
  • Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Poland
  • Medical University of Gdansk, Poland
  • Medical University of Gdansk, Poland
  • Medical University of Gdańsk, Poland
Bibliografia
  • Thomas MC. Diuretics, ACE inhibitors and NSAIDs--the triple whammy. Med J Aust. 2000;172(4):184-185.
  • Wrona W, Budka K, Filipiak KJ, Niewada M, Wojtyniak B, Zdrojewski T. Health outcomes and economic consequences of using angiotensin-converting enzyme inhibitors in comparison with angiotensin receptor blockers in the treatment of arterial hypertension in the contemporary Polish setting. Kardiol Pol. 2016;74(9):1016-24. doi: 10.5603/KP.a2016.0055.
  • Lapi F., Azoulay L., Yin H., Nessim S.J., Suissa S. Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study. BMJ. 2013;346:e8525.
  • Onuigbo MA. The nephrotoxic "triple whammy" of combining diuretics, ACE inhibitors, and NSAIDs. BMJ. 2013;346:f678.
  • Loboz KK, Shenfield GM. Drug combinations and impaired renal function -- the "triple whammy". Br J Clin Pharmacol. 2005;59(2):239-243. doi:10.1111/j.0306-5251.2004.2188.x.
  • Horowitz JD, Kennedy JA. Time to address the cardiac metabolic "triple whammy" ischemic heart failure in diabetic patients. J Am Coll Cardiol. 2006;48(11):2232-2234. doi:10.1016/j.jacc.2006.09.010.
  • Prieto-García L, Pericacho M, Sancho-Martínez SM, Sánchez Á, Martínez-Salgado C, López-Novoa JM, López-Hernández FJ. Mechanisms of triple whammy acute kidney injury. Pharmacol Ther. 2016;167:132-145. doi: 10.1016/j.pharmthera.2016.07.011.
  • Swieczkowski D, Merks P, Gruchala M, Jaguszewski MJ. The role of the pharmacist in the care of patients with cardiovascular diseases. Kardiol Pol. 2016;74(11):1319-1326. doi: 10.5603/KP.a2016.0136.
  • Camin RMG, Cols M, Chevarria JL, Osuna RG, Carreras M, Lisbona JM, Coderch J. Acute kidney injury secondary to a combination of renin-angiotensin system inhibitors, diuretics and NSAIDS: The Triple Whammy. Nefrol publicación Of la Soc Española Nefrol. 2015;35(2):197-206. doi:10.1016/j.nefro.2015.05.021.
  • Zulkifly H, Abdul WMS, Shaharuddin S, Chiau ML, Mat ZH. Be Cautious Of Triple Whammy!!! Value Health. 2014;17(7):A467. doi:10.1016/j.jval.2014.08.1312.
  • Fournier J-P, Sommet A, Durrieu G, et al. More on the 'Triple Whammy': antihypertensive drugs, non-steroidal anti-inflammatory agents and acute kidney injury - a case/non-case study in the French pharmacovigilance database. Ren Fail. 2014;36(7):1166-1168. doi:10.3109/0886022X.2014.917943.
  • Pavlovic J, Greenland P, Deckers JW, Brugts JJ, Kavousi M, Dhana K, Ikram MA, Hofman A, Stricker BH, Franco OH, Leening MJ. Comparison of ACC/AHA and ESC Guideline Recommendations Following Trial Evidence for Statin Use in Primary Prevention of Cardiovascular Disease: Results From the Population-Based Rotterdam Study. JAMA Cardiol.2016. doi:10.1001/jamacardio.2016.1577.
  • Walker DB, Jacobson TA. Initiating statins in the elderly: the evolving challenge. Curr Opin Endocrinol Diabetes Obes. 2008;15(2):182-187. doi:10.97/MED.0b013e3282f7cd6d.
  • Gustafsson M, Sjölander M, Pfister B, Jonsson J, Schneede J, Lövheim H. Drug-related hospital admissions among old people with dementia. Eur J Clin Pharmacol. 2016;72(9):1143-1153. doi:10.1007/s00228-016-2084-3.
  • da Costa FA, Silvestre L, Periquito C, Carneiro C, Oliveira P, Fernandes AI, Cavaco-Silva P. Drug-Related Problems Identified in a Sample of Portuguese Institutionalised Elderly Patients and Pharmacists' Interventions to Improve Safety and Effectiveness of Medicines. Drugs - real world outcomes. 2016;3:89-97. doi:10.1007/s40801-016-0061-x.
  • Ferreira JM, Galato D, Melo AC. Medication regimen complexity in adults and the elderly in a primary healthcare setting: determination of high and low complexities. Pharm Pract (Granada). 2015;13(4):659. doi:10.18549/PharmPract.2015.04.659.
  • Kanagala VS, Anusha A, Rao BS, Challa SR, Nalla KS, Gadde RS. A study of medication-related problems in stroke patients: A need for pharmaceutical care. J Res Pharm Pract. 5(3):222-225. doi:10.4103/2279-042X.185750.
  • Primejdie DP, Bojita MT, Popa A. Potentially inappropriate medications in elderly ambulatory and institutionalized patients: an observational study. BMC Pharmacol Toxicol. 2016;17(1):38. doi:10.1186/s40360-016-0081-x.
  • Swieczkowski D, Mogielnicki M, Cwalina N, Zuk G, Pisowodzka I, Ciecwierz D, Gruchala M, Jaguszewski M. Medication adherence in patients after percutaneous coronary intervention due to acute myocardial infarction: From research to clinical implications. Cardiol J. 2016 Jul 21. doi: 10.5603/CJ.a2016.0048.
Typ dokumentu
Bibliografia
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