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2013 | z. 77, nr 1 | 45--53
Tytuł artykułu

Naringenin Complexes with Copper Ions: Potentiometric Studies

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Flavanones belong to the group of active flavonoid compounds, rarely occurring in the plant kingdom and are found in many foodstuffs (naringenin and derivatives) and medicinal plant materials. Many studies have demonstrated a relationship between dietary intake of phenolic compounds and reduced risk of cancer and cardiovascular disease. Accordingly, during over several years, flavonoids have gained increasing interest and numerous studies have shown that they possess beneficial properties having a great influence on human health. Acid dissociation constants are believed to be the most useful physico-chemical parameters which describe the extent of ionization of functional groups as a function of pH. It is very important in research areas such as pharmaceutical drug discovery and development due to vital role in understanding the pharmacodynamic properties of new drug substances. Flavonoids are characterized by insolubility in water while they are soluble in organic solvents. Exploiting mixed solvents, especially organic solvent - water mixtures, enables a good alternative for researching on compounds which are inconspicuously soluble or insoluble in water. In this study the dissociation constant of naringenin and its complex with Cu(II) have been determined in aqueous - DMSO solvent mixtures to examine the dependence of their acid-base equilibria on number of substrates. (original abstract)
Opis fizyczny
  • Lodz University of Technology, Poland
  • Iwashina T. The Structure and Distribution of the Flavonoids in Plants. J Plant Res 2000, 113: 287-299.
  • Tomas-Barberan FA, Clifford MN. Flavanones, Chalcones and Dihydrochalcones -Nature, Occurence and Dietary Burden. J Sci Food Agric 2000, 80: 1073-1080.
  • Erlund I. Review of the Flavonoids Quercetin, Hesperetin and Naringenin: Dietary Sources, Bioactivities, Bioavailability and Epidemiology. Nutr Res 2004, 24: 851-874.
  • Santos KFR, Oliveira TT, Nagem TJ, Pinto AS, Oliveira MGA. Hypolipidaemic Effects of Naringenin, Rutin, Nicotinic Acid and Their Associations. Pharmacol Res 1999, 40: 493-496.
  • Hui-Ling W, Zheng-Yin Y, Bao-Dui W. Synthesis, characterization and the antioxidative activity of copper(II), zinc(II) and nickel(II) complexes with naringenin. Trans Met Chem 2006, 31: 470-474.
  • Pietta P. Flavonoids as Antioxidants. J Nat Prod 2000, 63: 1035-1042.
  • Jabbari M, Gharib F. Solute-Solvent Interaction Effects on Protonation Equilibrium of Some Water-Insoluble Flavonoids. J Solution Chem 2011, 40: 561-574.
  • Sari H, Al-Obaidi FN, Macit M, Atabey H. Study of the coordination properties of 1,2-bis(2,6-dimethphenylamino) glyoxime and determine the stability constant of its complexes with Ni(II), Cu(II) and Zn(II) metal ions in solution. J Sol Chem 2011, 40: 1618-1628.
  • Alderighi L, Gans P, Ienco A, Peters D, Sabatini A, Vacca A. Hyperquad simulation and speciation (HySS): a utility program for the investigation of equilibria involving soluble and partially soluble species. Coor Chem Rev 1999, 184: 311-318.
  • Lemanska K, Szymusiak H, Tyrakowska B, Zielinski R. A.E.M.F. Soffers: I.M.C.M. Rietjens. Free Radic Biol Med 2001, 31: 869.
  • Agrawal PK, Schneider HJ. Tetrahedron Lett 1983, 24: 177-180.
  • Karadag R, Erdogan G, Bayar M, Dolen E. Rev Anal Chem 2007, 26: 169-186.
  • Medvidović-Kosanović M, Šeruga M, Jakobek L, Novak I. Electrochemical and antioxidant properties of rutin. Collect Czech Chem Commun 2010, 75(5): 547-561.
  • Dyba M, Solinas S, Culeddu N, Ganadu M-L, Kozłowski H. Cu(II) complexes with rutin. Polish J Chem 1999, 73: 873-878.
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