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Czasopismo
2023 | 9 | nr 1 | 40--45
Tytuł artykułu

Ashwagandha (Withania somnifera) - influence on sleep: review

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Introduction: Ashwagandha (Withania somnifera) is a plant found on the Indian subcontinent. The health-promoting properties attributed to it have been largely verified in numerous studies over the past 20 years. This article reviews studies on the effects of ashwagandha supplementation on sleep, its deprivation, and studies analyzing the mechanisms determining such effects. Materials and methods: A review of the literature available in the PubMed database was carried out, using the key words: "ashwagandha" ; "sleep" ; "insomnia", "withania", "somnifera", "withanolide", "withaferin". Results: Ashwagandha has a positive effect on the quality and length of sleep. It is indicated that it improves sleep parameters among both insomniacs and healthy people. In addition, it has been proven to reduce oxidative stress under conditions of sleep deprivation. Ashwagandha's positive effects on sleep have been shown to be related to its effects on GABA-nergic transmission, and the chemical responsible for the plant's sleep induction is triethylene glycol. Its regular use increases dopamine levels in the brain and could potentially be useful in treating the sleep-related disorder restless legs syndrome. Conclusions: The use of ashwagandha is a potential direction for treating sleep disorders and improving sleep quality in healthy individuals. There is a need for further development and studies on larger groups of patients to exploit its potential.(original abstract)
Słowa kluczowe
Czasopismo
Rocznik
Tom
9
Numer
Strony
40--45
Opis fizyczny
Twórcy
  • Uniwersytet Medyczny w Lublinie
autor
  • Uniwersytet Medyczny w Lublinie
  • Uniwersytet Medyczny w Lublinie
  • Uniwersytet Medyczny w Lublinie
  • Uniwersytet Medyczny w Lublinie
Bibliografia
  • Langade D, Thakare V, Kanchi S, Kelgane S. Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study. J Ethnopharmacol. 2021 Jan 10;264:113276. doi: 10.1016/j.jep.2020.113276. Epub 2020 Aug 17. PMID: 32818573.
  • Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus. 2019 Sep 28;11(9):e5797. doi: 10.7759/cureus.5797. PMID: 31728244; PMCID: PMC6827862.
  • Deshpande A, Irani N, Balkrishnan R, Benny IR. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Med. 2020 Aug;72:28-36. doi: 10.1016/j.sleep.2020.03.012. Epub 2020 Mar 21. PMID: 32540634.
  • Kaushik MK, Kaul SC, Wadhwa R, Yanagisawa M, Urade Y. Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. PLoS One. 2017 Feb 16;12(2):e0172508. doi: 10.1371/journal.pone.0172508. PMID: 28207892; PMCID: PMC5313221.
  • Candelario M, Cuellar E, Reyes-Ruiz JM, Darabedian N, Feimeng Z, Miledi R, Russo-Neustadt A, Limon A. Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAρ receptors. J Ethnopharmacol. 2015 Aug 2;171:264-72. doi: 10.1016/j.jep.2015.05.058. Epub 2015 Jun 9. PMID: 26068424.
  • Murthy SV, Fathima SN, Mote R. Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo Experimental Models. Prev Nutr Food Sci. 2022 Mar 31;27(1):108-120. doi: 10.3746/pnf.2022.27.1.108. PMID: 35465115; PMCID: PMC9007714.
  • Kumar A, Kalonia H. Effect of Withania somnifera on Sleep-Wake Cycle in Sleep-Disturbed Rats: Possible GABAergic Mechanism. Indian J Pharm Sci. 2008 Nov;70(6):806-10. doi: 10.4103/0250-474X.49130. PMID: 21369449; PMCID: PMC3040882.
  • Chaudhari KS, Tiwari RR, Chaudhari SS, Joshi SV, Singh HB. Withania somnifera as an Adjunctive Treatment for Refractory Restless Legs Syndrome in Parkinson's Disease: A Case Report. Cureus. 2021 Dec 28;13(12):e20775. doi: 10.7759/cureus.20775. PMID: 35111460; PMCID: PMC8793665.
  • RajaSankar S, Manivasagam T, Sankar V, Prakash S, Muthusamy R, Krishnamurti A, Surendran S. Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson's disease model mouse. J Ethnopharmacol. 2009 Sep 25;125(3):369-73. doi: 10.1016/j.jep.2009.08.003. Epub 2009 Aug 8. PMID: 19666100.
  • Prakash J, Chouhan S, Yadav SK, Westfall S, Rai SN, Singh SP. Withania somnifera alleviates parkinsonian phenotypes by inhibiting apoptotic pathways in dopaminergic neurons. Neurochem Res. 2014 Dec;39(12):2527-36. doi: 10.1007/s11064-014-1443-7. Epub 2014 Nov 18. PMID: 25403619.
  • Wang YY, Ma WW, Peng IF. Screening of sleep assisting drug candidates with a Drosophila model. PLoS One. 2020 Jul 29;15(7):e0236318. doi: 10.1371/journal.pone.0236318. PMID: 32726319; PMCID: PMC7390450.
  • Kelgane SB, Salve J, Sampara P, Debnath K. Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study. Cureus. 2020 Feb 23;12(2):e7083. doi: 10.7759/cureus.7083. PMID: 32226684; PMCID: PMC7096075.
  • Kumar A, Kalonia H. Protective effect of Withania somnifera Dunal on the behavioral and biochemical alterations in sleep-disturbed mice (Grid over water suspended method). Indian J Exp Biol. 2007 Jun;45(6):524-8. PMID: 17585686.
  • Manchanda S, Mishra R, Singh R, Kaur T, Kaur G. Aqueous Leaf Extract of Withania somnifera as a Potential Neuroprotective Agent in Sleep-deprived Rats: a Mechanistic Study. Mol Neurobiol. 2017 May;54(4):3050-3061. doi: 10.1007/s12035-016-9883-5. Epub 2016 Apr 1. PMID: 27037574.
  • Kaur T, Singh H, Mishra R, Manchanda S, Gupta M, Saini V, Sharma A, Kaur G. Withania somnifera as a potential anxiolytic and immunomodulatory agent in acute sleep deprived female Wistar rats. Mol Cell Biochem. 2017 Mar;427(1-2):91-101. doi: 10.1007/s11010-016-2900-1. Epub 2016 Dec 21. PMID: 28004351.
  • Suganya K, Kayalvizhi E, Yuvaraj R, Chandrasekar M, Kavitha U, Konakanchi Suresh K. Effect of Withania Somnifera on the antioxidant and neurotransmitter status in sleep deprivation induced Wistar rats. Bioinformation. 2020 Aug 31;16(8):631-637. doi: 10.6026/97320630016631. PMID: 33214752; PMCID: PMC7649022.
  • Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2021 Nov 30;2021:8254344. doi: 10.1155/2021/8254344. PMID: 34858513; PMCID: PMC8632422.
  • Salve J, Pate S, Debnath K, Langade D. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus. 2019 Dec 25;11(12):e6466. doi: 10.7759/cureus.6466. PMID: 32021735; PMCID: PMC6979308.
  • Holvoet H, Long DM, Law A, McClure C, Choi J, Yang L, Marney L, Poeck B, Strauss R, Stevens JF, Maier CS, Soumyanath A, Kretzschmar D. Withania somnifera Extracts Promote Resilience against Age-Related and Stress-Induced Behavioral Phenotypes in Drosophila melanogaster; a Possible Role of Other Compounds besides Withanolides. Nutrients. 2022 Sep 22;14(19):3923. doi: 10.3390/nu14193923. PMID: 36235577; PMCID: PMC9573261.
  • Vijay K. Bharti, Jitendra K. Malik, Ramesh C. Gupta, Chapter 52 - Ashwagandha: Multiple Health Benefits, Nutraceuticals, Academic Press, 2016, Pages 717-733, ISBN 9780128021477, https://doi.org/10.1016/B978-0-12-802147-7.00052-8.
  • Gorelick J, Rosenberg R, Smotrich A, Hanuš L, Bernstein N. Hypoglycemic activity of withanolides and elicitated Withania somnifera. Phytochemistry. 2015 Aug;116:283-289. doi: 10.1016/j.phytochem.2015.02.029. Epub 2015 Mar 18. PMID: 25796090.
  • Sikandan A, Shinomiya T, Nagahara Y. Ashwagandha root extract exerts anti-inflammatory effects in HaCaT cells by inhibiting the MAPK/NF-κB pathways and by regulating cytokines. Int J Mol Med. 2018 Jul;42(1):425-434. doi: 10.3892/ijmm.2018.3608. Epub 2018 Apr 2. PMID: 29620265.
  • Bhatnagar M, Sharma D, Salvi M. Neuroprotective effects of Withania somnifera dunal.: A possible mechanism. Neurochem Res. 2009 Nov;34(11):1975-83. doi: 10.1007/s11064-009-9987-7. Epub 2009 May 15. PMID: 19444606.
Typ dokumentu
Bibliografia
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Identyfikator YADDA
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