Microbial alterations of oral cavity and their association with Pancreatic Cancer

• Autorzy: Zuzanna Radziejowska , Alicja Bielak , Jakub Gryta , Karolina Iwan , Martyna Janczewska , Maria Kalicka , Tomasz Krysa , Agata Kolasa , Magdalena Szklarz
• Języki publikacji: EN

Abstrakty

EN

Introduction: Pancreatic Cancer (PC), while relatively infrequent, remains one of the deadliest cancers as a result of late diagnosis and absence of preventive measures. Over 50 % of patients diagnosed with PC already suffer metastasis. Combined with lack of effective treatment, the need arises for universal biomarkers specific to PC. In the last decades the importance of human microbiota in its upholding of the body homeostasis has been under radar, in special regards to its association to cancer. Several species of oral microbiome have been linked to increased or decreased risk of developing pancreatic cancer, most notably P.gingivalis and Fusobacteria. Purpose of the study: The aim of this study is to collect and summarize existing evidence on connection of oral microbiome and pancreatic cancer, as well as to assess their potential use in diagnostics of PC . Material and method: Literature review was performed, in English databases, using keywords : cancer, pancreatic cancer, pancreatic cancer prevention, oral microbiome, microbe variation, microbial biomarkers. Results and conclusions: In our systematic review, evident differences between microbial architecture of PC patients and healthy individuals were observed. The data on association between microbiota and risk of developing cancer is limited, however it still provides evidence for relationship between microbial composition and incidence of pancreatic cancer.(original abstract)

Słowa kluczowe

EN

Sport; Illness; Health; Quality of life; Cancer

PL

Sport; Choroby; Zdrowie; Jakość życia; Choroby nowotworowe

• Czasopismo: Quality in Sport
• Rocznik: 2023
• Tom: 9
• Numer: nr 1
• Strony: 71--77

Twórcy

autor

Zuzanna Radziejowska

• 1 Military Clinical Hospital in Lublin

autor

Alicja Bielak

• 1 Military Clinical Hospital in Lublin

autor

Jakub Gryta

• 1 Military Clinical Hospital in Lublin

autor

Karolina Iwan

• 1 Military Clinical Hospital in Lublin

autor

Martyna Janczewska

• Independent Public Clinical Hospital No. 4 in Lublin

autor

Maria Kalicka

• 1 Military Clinical Hospital in Lublin

autor

Tomasz Krysa

• Specialist Hospital of Stefan Cardinal Wyszyński in Lublin

autor

Agata Kolasa

• 1 Military Clinical Hospital in Lublin

autor

Magdalena Szklarz

• 1 Military Clinical Hospital in Lublin

Bibliografia

• Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-249. doi:10.3322/caac.21660
• Gillen S, Schuster T, Meyer Zum Büschenfelde C, Friess H, Kleeff J. Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. PLoS Med. 2010;7(4):e1000267. Published 2010 Apr 20. doi:10.1371/journal.pmed.1000267
• Zhao Z, Liu W. Pancreatic Cancer: A Review of Risk Factors, Diagnosis, and Treatment. Technol Cancer Res Treat. 2020;19:1533033820962117. doi:10.1177/1533033820962117
• Tonini V, Zanni M. Pancreatic cancer in 2021: What you need to know to win. World J Gastroenterol 2021; 27(35): 5851-5889 [PMID: 34629806 DOI: 10.3748/wjg.v27.i35.5851]
• Fan X, Alekseyenko AV, Wu J, et al. Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. Gut. 2018;67(1):120-127. doi:10.1136/gutjnl-2016-312580
• Chattopadhyay I, Verma M, Panda M. Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer. Technol Cancer Res Treat. 2019;18:1533033819867354. doi:10.1177/1533033819867354
• Karpiński TM. Role of Oral Microbiota in Cancer Development. Microorganisms. 2019;7(1):20. Published 2019 Jan 13. doi:10.3390/microorganisms7010020
• Castellarin M, Warren RL, Freeman JD, et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 2012;22(2):299-306. doi:10.1101/gr.126516.111
• Park, J.Y.; Forman, D.; Waskito, L.A.; Yamaoka, Y.; Crabtree, J.E. Epidemiology of Helicobacter pylori and CagA-Positive Infections and Global Variations in Gastric Cancer. Toxins 2018, 10, 163. [CrossRef]
• Michaud DS, Izard J, Wilhelm-Benartzi CS, et al. Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. Gut 2013;62:1764-70.
• Gnanasekaran J, Binder Gallimidi A, Saba E, et al. Intracellular Porphyromonas gingivalis Promotes the Tumorigenic Behavior of Pancreatic Carcinoma Cells. Cancers (Basel). 2020;12(8):2331. Published 2020 Aug 18. doi:10.3390/cancers12082331
• Wei AL, Li M, Li GQ, et al. Oral microbiome and pancreatic cancer. World J Gastroenterol. 2020;26(48):7679-7692. doi:10.3748/wjg.v26.i48.7679
• Herremans KM, Riner AN, Cameron ME, et al. The oral microbiome, pancreatic cancer and human diversity in the age of precision medicine. Microbiome. 2022;10(1):93. Published 2022 Jun 15. doi:10.1186/s40168-022-01262-7
• Vogtmann E, Han Y, Caporaso JG, et al. Oral microbial community composition is associated with pancreatic cancer: A case-control study in Iran. Cancer Med. 2020;9:797-806. https://doi.org/10.1002/ cam4.2660
• Torres PJ, Fletcher EM, Gibbons SM, Bouvet M, Doran KS, Kelley ST. Characterization of the salivary microbiome in patients with pancreatic cancer. PeerJ. 2015;3:e1373. Published 2015 Nov 5. doi:10.7717/peerj.1373
• Farrell JJ, Zhang L, Zhou H, et al. Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer. Gut. 2012;61(4):582-588. doi:10.1136/gutjnl-2011-300784
• Petrick JL, Wilkinson JE, Michaud DS, et al. The oral microbiome in relation to pancreatic cancer risk in African Americans. Br J Cancer. 2022;126(2):287-296. doi:10.1038/s41416-021-01578-5
• Kabwe M, Dashper S, Tucci J. The Microbiome in Pancreatic Cancer-Implications for Diagnosis and Precision Bacteriophage Therapy for This Low Survival Disease. Front Cell Infect Microbiol. 2022;12:871293. Published 2022 May 19. doi:10.3389/fcimb.2022.871293
• Abed J, Maalouf N, Manson AL, et al. Colon Cancer-Associated Fusobacterium nucleatum May Originate From the Oral Cavity and Reach Colon Tumors via the Circulatory System. Front Cell Infect Microbiol. 2020;10:400. Published 2020 Aug 7. doi:10.3389/fcimb.2020.00400
• Sun H, Zhao X, Zhou Y, et al. Characterization of Oral Microbiome and Exploration of Potential Biomarkers in Patients with Pancreatic Cancer. Biomed Res Int. 2020;2020:4712498. Published 2020 Oct 31. doi:10.1155/2020/4712498
• Michaud DS, Fu Z, Shi J, Chung M. Periodontal Disease, Tooth Loss, and Cancer Risk. Epidemiol Rev. 2017;39(1):49-58. doi:10.1093/epirev/mxx006
• Nasidze I, Li J, Quinque D, Tang K, Stoneking M. Global diversity in the human salivary microbiome. Genome Res. 2009;19(4):636-643. doi:10.1101/gr.084616.108
• Stasiewicz M, Kwaśniewski M, Karpiński TM. Microbial Associations with Pancreatic Cancer: A New Frontier in Biomarkers. Cancers (Basel). 2021;13(15):3784. Published 2021 Jul 27. doi:10.3390/cancers13153784
• Guo S, Li L, Xu B, et al. A Simple and Novel Fecal Biomarker for Colorectal Cancer: Ratio of Fusobacterium Nucleatum to Probiotics Populations, Based on Their Antagonistic Effect. Clin Chem. 2018;64(9):1327-1337. doi:10.1373/clinchem.2018.289728
• Maisonneuve P, Amar S, Lowenfels AB. Periodontal disease, edentulism, and pancreatic cancer: a meta-analysis. Ann Oncol. 2017;28(5):985-995. doi:10.1093/annonc/mdx019

Identyfikatory

DOI

10.12775/QS.2023.09.01.009