Evaluation of design and insertion analysis of a conical shaped polymeric based microneedle for transdermal drug delivery applications

• Autorzy: Aswani Kumar Gera , Rajesh Kumar Burra
• Języki publikacji: EN

Abstrakty

EN

Transportation of drug through parental routes are conventionally followed through hypodermic injection methods, where hypodermic injections are administered into the human skin for drug release. However, there are some issues observed when these hypodermic needles are being used, there are instances where the needle is being inserted leaves some needle fractures in the skin. To cater to the issue scientific researchers are voraciously working on designing and developing polymeric type of microneedle structures for various medical diagnostic applications for glucose monitoring, drug delivery, and other applications. This article presents the structural design of a conicalshaped polymeric microneedle and the insertion force while being pierced into the skin. Simulations at different insertion angles on microneedle are analyzed by arriving with total needle displacements in the process of insertion. The von mises stress is also analyzed with applied force at different insertion angles resulted in incremental change in stress exerted by the microneedle. The resultant stress is below the yield stress which makes the microneedle pierce into the skin without breakage.(original abstract)

Słowa kluczowe

EN

Polymers; Medications; Scientific research

PL

Polimery; Leki; Badania naukowe

• Czasopismo: Acta Innovations
• Rocznik: 2023
• Numer: nr 46
• Strony: 53--64

Twórcy

autor

Aswani Kumar Gera

• chool of Technology GITAM, Deemed to be University, Visakhapatnam, India

autor

Rajesh Kumar Burra

• chool of Technology GITAM, Deemed to be University, Visakhapatnam, India

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Identyfikatory

DOI

https://doi.org/10.32933/ActaInnovations.46.4