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Tytuł artykułu
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Warianty tytułu
Języki publikacji
Abstrakty
Psoriasis vulgaris is a common, worldwide autoimmune skin disorder characterized by T-cells mediated hyperproliferation of keratinocytes. The feature of T-cells arbitrated psoriatic lesions is the epidermal infiltration of oligoclonal CD8+T-cells and also of CD4+T-cells in the dermis. Psoriatic scratches are identified by red and enlarged lesions along with silver whitish scales. In this article, we propose a mathematical model for psoriasis, involving a set of differential equations, concerning T-cells, dendritic cells and epidermal keratinocytes. We introduce T-cell proliferation in the system, where T-cells are generated through expansion of accessible CD4+T-cells from precursors. We are interested in observing how the cell biological system develops through T-cell proliferation in presence of control with respect to T-cells and keratinocytes. We study the model in both implicit and explicit ways and measure the effect of drug on the system through impulsive drug therapy. (original abstract)
Twórcy
autor
- Jadavpur University, Kolkata, India
autor
- Jadavpur University, Kolkata, India
Bibliografia
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
bwmeta1.element.ekon-element-000171304125