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2013 | 42 | nr 2 | 365--386
Tytuł artykułu

T-cell Proliferation on Immunopathogenic Mmechanism of Psoriasis: a Control Based Theoretical Approach

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Psoriasis vulgaris is a common, worldwide autoimmune skin disorder characterized by T-cells mediated hyperproliferation of keratinocytes. The feature of T-cells arbitrated psoriatic lesions is the epidermal infiltration of oligoclonal CD8+T-cells and also of CD4+T-cells in the dermis. Psoriatic scratches are identified by red and enlarged lesions along with silver whitish scales. In this article, we propose a mathematical model for psoriasis, involving a set of differential equations, concerning T-cells, dendritic cells and epidermal keratinocytes. We introduce T-cell proliferation in the system, where T-cells are generated through expansion of accessible CD4+T-cells from precursors. We are interested in observing how the cell biological system develops through T-cell proliferation in presence of control with respect to T-cells and keratinocytes. We study the model in both implicit and explicit ways and measure the effect of drug on the system through impulsive drug therapy. (original abstract)
Rocznik
Tom
42
Numer
Strony
365--386
Opis fizyczny
Twórcy
  • Jadavpur University, Kolkata, India
  • Jadavpur University, Kolkata, India
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.ekon-element-000171304125

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