Prozdrowotne właściwości resweratrolu

• Autorzy: Aneta Kopeć , Ewa Piątkowska , Teresa Leszczyńska , Renata Bieżanowska-Kopeć

Warianty tytułu

Health Stimulating Properties of Resveratrol

• Języki publikacji: PL

Abstrakty

Resweratrol (3,5,4'-trihydroksy-trans-stilben) jest naturalną fitoaleksyną, syntetyzowaną m.in. w skórkach winogron w odpowiedzi na infekcje grzybicze, stres oksydacyjny oraz promieniowanie UV. W wysokim stężeniu występuje również w winie, głównie czerwonym. Związek ten ma szeroki zakres aktywności biologicznej, m.in. właściwości przeciwzapalne, antyangiogenne, antyoksydacyje oraz przeciwnowotworowe. Ponadto chroni organizm przed chorobami układu krążenia i neurodegeneracyjnymi, hamuje oksydację cholesterolu frakcji LDL, agregację płytek krwi i angiogenezę. (abstrakt oryginalny)

EN

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural phytoalexin, synthesized, among other things, in grape skins as a response to fungal infection, oxidative stress, and UV irradiation. High concentration levels thereof are found in wine, mainly in red wine. This compound has a wide range of biological activities, for example: anti-inflammatory, anti-angiogenic, antioxidative, and anti-cancer effects. Additionally, it protects human organisms against cardiovascular and neurodegenerative diseases, inhibits the oxidation of LDL fraction of cholesterol, suppresses platelet aggregation in blood and angiogenesis. (original abstract)

Słowa kluczowe

PL

Żywność; Właściwości zdrowotne produktu; Aktywność przeciwutleniająca; Zdrowie; Choroby

EN

Food; Health properties of the product; Antioxidant activity; Health; Illness

• Czasopismo: Żywność: nauka - technologia - jakość
• Rocznik: 18 (2011)
• Numer: nr 5 (78)
• Strony: 5--15

Twórcy

autor

Aneta Kopeć

• Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie

autor

Ewa Piątkowska

• Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie

autor

Teresa Leszczyńska

• Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie

autor

Renata Bieżanowska-Kopeć

• Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie

Bibliografia

• [1] Abril M., Negueruela A.I., Perez C., Juan T., Estopanan G.: Preliminary study of resveratrol content in Aragón red and rose wines. Food Chem., 2005, 4 (92), 729-736.
• [2] Anekonda T.S., Reddy P.H.: Neuronal protection by sirtuins in Alzheimer's disease. J. Neurochem., 2006, 2 (96), 305-313.
• [3] Baatout S., Derradji H., Jacquet P., Ooms D., Michaux A., Mergeay M.: Enhanced radiation-induced apoptosis of cancer cell lines after treatment with resveratrol. Int. J. Mol. Med., 2004, 6 (13), 895-902.
• [4] Berge G., Ovrebo S., Botnen I.V., Hewer A., Phillips D.H., Haugen A., Mollerup S.: Resveratrol inhibits benzo[a]pyrene-DNA adduct formation in human bronchial epithelial cells. Br. J. Cancer., 2004, 19 (91), 333-338.
• [5] Buryanovskyy L., Fu Y., Boyd M., Ma Y., Hsich T.C., Wu J.M., Zhang Z.: Crystal structure of quinone reductase 2 in complex with resveratrol. Biochemistry, 2004, 36 (43), 11417-11426.
• [6] Cao Z., Li Y.: Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomiocytes: production against oxidative and electrophillie injury. Eur. J Pharmacol., 2004, 1-2 (489), 39-48.
• [7] Crowell J.A., Korytko P.J., Morrissey R.L., Booth T.D., Levine B.S.: Resveratrol - associated renal toxicity. Toxicol. Sci., 2004, 2 (82), 614-619.
• [8] Dipak K.D., Maulik N.: Resveratrol in cardioprotection. A therapeutic promise of alternative medicine. Molecular Inventions, 2006, 1 (6), 36-47.
• [9] Docherty J.J., Smith J.S., Fu M.M., Stoner T., Booth T.: Effect of topically applied resveratrol on cutaneous herpes simplex virus infections in hairless mice. Antiviral Res., 2004, 1 (61), 19-26.
• [10] Donnelly L.E., Newton R., Kennedy G.E., Fenwick P.S., Leung R.H., Ito K., Russell R.E., Barnes P.J.: Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am. J. Physiol. Lung Cell Mol. Physiol., 2004, 4 (287), 774-783.
• [11] Espi'n J, C, Garci'a-Conesa M.T., Toma's-Barbera'n F.A Carlos J.E., Garci'a-Conesa M.T., Francisco A.T.B.: Nutraceuticals: Facts and fiction. Phytochemistry, 2007, 22-24 (68), 2986-3008.
• [12] Evers D.L., Wang X., Huong S.M., Huang D.Y., Huang E.S.: 3,4',5-trihydroxy-trans-stilbene (resveratrol) inhibits human cytomegalovirus replication and virus-induced cellular signaling. Antiviral Res., 2004, 2 (63), 85-95.
• [13] Fukao H., Ijiri Y., Miura M., Hashimoto M., Yamashita T., Fukunaga C., Oiwa K., Kawai Y., Suwa M., Yama-Moto J.: Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice. Blood Coagul. Fibrinolysis, 2004, 6 (15), 441-446.
• [14] Gu X., Chu Q., O'Dwyer M., Zeece M.: Analysis of resveratrol in wine by capillary electrophoresis. J. Chromatogr. A, 2000, 1-2 (881), 471-481.
• [15] Hung L.M., Su M.J., Chen J.K.: Resveratrol protects myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms. Free Radic. Biol. Med., 2004, 6 (36), 774-781.
• [16] Hung L.M., Chen J.K., Huang S.S., Lee R.S., Su M.J.: Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc. Res., 2000, 3 (47), 549-555.
• [17] Hunter R.L., Dragicevic N., Seifert K., Choi D.Y., Liu M., Kim H.C., Cass W.A., Sullivan P.G., Bing G.: Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. J. Neurochem, 2007, 5 (100), 1375-1386.
• [18] Karlsson J., Emgard M., Brundin P., Burkitt M.J.: Trans-resveratrol protects embryonic mesencephalic cells from tert-butyl hydroperoxide: electron paramagnetic resonance spin trapping evidence for a radical scavenging mechanism. J. Neuroch., 2000, 1 (75), 141-150.
• [19] Kopp P.: Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the "French paradox"?. Eur. J Endocrinol., 1998, 6 (133), 619-620.
• [20] Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P.: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1a.. Cell, 2006, 6 (127), 1-14.
• [21] Le Corre L., Fustier P., Chalabi N., Bignon Y.J., Bernard-Gallon D.: Effects of resveratrol on the expression of a panel of genes interacting with the BRCA1 oncosuppressor in human breast cell lines. Clin. Chim. Acta, 2004, 1-2 (344), 115-121.
• [22] Lorenz P., Roychowdhury S., Engelmann M., Wolf G., Horn T.F.: Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cells. Nitric Oxide, 2003, 2 (9), 64-76.
• [23] Martin A.R., Villegas I., La Casa C., de la Lastra C.A.: Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochem. Pharmacol., 2004, 7 (67), 1399-1410.
• [24] Medina-Bolivar F., Condori J., Rimando A.M., Hubstenberger J., Shelton K., O'Keefe S.F., Bennett S., Dolan M.C.: Production and secretion of resveratrol in hairy root cultures of peanut. Phytochemistry, 2007, 14 (68), 1992-2003.
• [25] Montero C., Cristescu S.M., Jimenez J.B., Orea J.M., te Lintel Hekkert S., Harren F.J.M., Gonzalez Urena A.: Trans-resveratrol and grape disease resistance. A dynamical study by high-resolution laser-based techniques. Plant Physiology, 2003, 1 (131), 129-138.
• [26] Obisesan T. O., Hirsch R., Kosoko O., Carlson L., Parrott M.: Moderate wine consumption is associated with decreased odds of developing age-related macular degeneration in NHANES-1. J. Am. Geriat. Soc., 1998, 1 (46), 1-7.
• [27] Orallo F., Alvarez E., Camina M., Leiro J.M., Gomez E., Fernandez P.: The possible implication of trans-resveratrol in the cardioprotective effects of long-term moderate wine consumption. Mol. Pharmacol., 2002, 2 (61), 294-302.
• [28] Pervaiz S.: Resveratrol: from grapevines to mammalian biology. FASEB J., 2003, 17, 1975-1985.
• [29] Piver B., Fer M., Vitrae X., Merillon J.M., Dreano Y., Berthou F., Lucas D.: Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Biochem. Pharmacol., 2004, 4 (68), 773-782.
• [30] Prasongsidh B.C., Skurray G.R.: Capillary electrophoresis analysis of trans- and cis-resveratrol, quercetin, catechin and gallic acid in wine. Food Chemistry, 1998, 3 (62), 355-358.
• [31] Renaud S., de Lorgeril M.: Wine, alcohol, platelets and the French paradox for coronary heart disease. Lancet., 1992, 339 (8808), 1523-1526.
• [32] Rivera L., Moron R., Zaruzelo A., Galisteo M.: Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochem. Pharmacol., 2009, 6 (77), 1033-1063.
• [33] Saiko P., Szakmary A., Jaeger W., Szekeres T.: Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad? Mutat. Res., 2008, 1-2 (658), 68-94.
• [34] Savaskan E., Olivieri G., Meier F., Seifritz E., Wirz-Justice A., Muller-Spahn F.: Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity. Gerontology, 2003, 6 (49), 380-383.
• [35] Stervbo U., Vang O., Bonnesen Ch.: A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine. Food Chem., 2007, 2 (101), 449-457.
• [36] Todaro A., Palmeri R., Barbagallo R.N., Pifferi P.G., Spagna G.: Increase of trans-resveratrol in typical Sicilian wine using ß-glucosidase from various sources. Food Chem., 2008, 4 (107), 1570-1575.
• [37] Zdrojewicz Z., Belowska-Bień K.: Resweratrol - działanie i znaczenie kliniczne. Adv. Clin. Exp. Med., 2005, 5 (14), 1051-1056.